POTENTIAL HEALTH EFFECT OF NEEM
INTRODUCTION: Neem is a known as “wonder tree” and its scientific names is Azadirachta indica and is known for its health promoting properties and offer a wide range of health benfits for several diseases and also act as a natural source of insecticides, pesticides and agrochemicals also [Girish, K., & Shankara, B. S. (2008)]. Neem tree grown mainly in a well-drained deep and sandy loam soil and has more 300 bioactive compounds [Hao, F et-al 2014]. Numerous substances, including limonoids like nimbin, nimbidin, nimbinin , 6-desacetylnimbinene with a variety of pharmacological effects, azadirachtin, and quercetin, are available in numerous parts of this tree .[ Rahmani, et-al 2018]. During researches, its componenets were discovered to have higher anti-oxidant, antibacterial, antifungal, antiviral, hepatoprotective, anti-microbial, and anti-cancerous effects. Neem has been extensively used in Ayurveda, Unani and Homeopathic medicine [Tiwari R et-al ,2014]. Additionally, it exhibits therapeutic implications in the modification of cell signalling pathways implicated in the control of cancer. Neem and its component may also present a potential contender because to its wider pharmacological activity in tumour prevention and treatment. The earliest Sanskrit medical writings refer to the benefits of Neem’s fruits, seeds, oil, leaves, roots and bark. The word Azadirachta indica comes from a persian word “Azad dirakhat-I-Hind” meaning “noble or free tree of India”.Neem has two closely related species of neem, are referred to as Indian neem (margosa tree) and Persian lilac, respectively. The neem is known as Sarbaroganibarini because its Sanskrit name, Arishtha, means “reliever of disease.” In India, the tree has always been recognized to as the “village dispensary”[Agrawal and D. P. (2001)].This article provides a summary of the potential health-promoting effects of neem and its components through controlling biological processes. The Neem tree’s botanical name is Azadirachta indica. Neem is mainly a Tracheophytes and it is a member of the Meliacea family and sub-family of Angiosperm Order is Rutales, and is well-known for its vast range of pharmacological actions. The neem tree may be found all throughout India.It flourishes in locations with sub-arid to sub-humid environments, with annual rainfall ranging from 400 to 1200 mm. It can grow in areas with annual rainfall of less than 400 mm, however it is heavily reliant on ground water levels in such instances. Since ancient times, neem tree extracts has a variety of health-promoting properties that have been widely used in health management.It’s offers possible health benefits, including being an antimalarial, insecticidal, anti-filarial ,abortifacient, antibacterial, antifungal, antiviral, antitumor, anti-pyretic, anti-spermatogenic, anti-yeast, and immunomodulator according to National Research Council (1992). It the is known to be a plant that is widely distributed in several tropical and semi-tropical nations, including Bangladesh, Pakistan, and India[Hao, F et-al 2014]. It can acquire resistance ranging from hot to extremely hot. It can not survive temperatures below 40C. Neem may grow in a wide range of soils, although it grows best in well-drained deep and sandy loam (pH 6.2-7.0). From various parts of the plant, phytochemicals such as quercetin and azadirachtin, as well as liminoids such as nimbin, nimbinin, and nimbidin, have been isolated. Furthermore, the leaves contain nimbanene, 6-desacetylnimbinene, nimbandiol, nimbolide, ascorbic acid, n-hexacosanol, nimbiol, various amino acids, and other compounds.[ Rahmani, et-al 2018] .From the ancient time neem is used to treat a range of illnesses in Indian Ayurvedic medicine, Homoeopathic medicine, and Unani medicine[Tiwari R et-al ,2014;] An incredible natural resource, neem has a broad range of chemically diversified and structurally complex metabolites with special biological properties. Neem has been obtained from a variety of ecological niches, and it’s noteworthy to notice that out 400 bioactive compounds of various types have already been discovered. This undoubtedly confirms its historical usage and potential health benefits in traditional medicine [Kharwar et-al,2020] 2] PLANT DESCRIPTION AND CLASSIFICATION: Neem is a fast-growing tree that has a straight trunk with long spreading branches that has 5-15 leaflets per leaf and are compound and imparipinnate in nature and is a tropical evergreen related to mahogany. They are reportedly said to live up to 200 years.The bark is rough dark brown with extensive longitudinal cracks divided by flat ridges and varies in different size according to the age of the plant is taken [Alzohairy and M. A. (2016)]. It contains several blooming panicles, most of which are in the leaf axils and its flower has pentamerous, little, white or pale yellow in colour that are mildly sweet and bisexual when bloom. Neem trees have one or two ellipsoidal, 1-2 cm long seeded drupes. When ripe, they become greenish, and their seeds are ovoid or spherical in shape. When young, the fruits are green, becoming yellow as they develop, and have a garlic-like scent. With a diameter of up to 1.2cm, the trunk is relatively short and straight, and the bark is rough, hard, scaly, and pale grey to reddish brown in colour[Upadhayay et-al ,2014]. The leaves are bitter in taste and new leaves appear to bloom in March and April. The oil found in the seed has potent medicinal and pharmacological properties. Juicing the kernels yields the oil readily. Depending on where you reside, fruits mature between April and August. [Hashmat, I.,et-al 2012]. It can grow on practically any sort of soil, including clayey, saline, and alkaline soil, but it flourishes in deep, well-drained soil with good subsoil water and black cotton soil. Because of their special potential to extract calcium, neem trees can neutralise acidic soils.[ Girish, K., & Shankara, B. S. (2008)] Scientific Classification table for Neem Tree: KINGDOM PLANTEA FAMILY MELIACEAE SUBFAMILY MELIOIDEAE CLASS MAGNOLIOPSIDA ORDER RUTALES SUBORDER RUTINAE GENUS AZADIRACHTA SPECIES INDICA TABLE 1: SCIENTIFIC CLASSIFICATION OF NEEM TREE [Eid et-al,2017] 3] NEEM AS A MIRACLE TREE OF INDIA: As we all know the scientific name of neem is Azadirachta indica. The word Azadirachta indica comes from a persian word “Azad dirakhat-I-Hind” meaning “noble or free tree of India”.Neem has two closely related species of neem, are referred to as Indian neem (margosa tree) and Persian lilac, respectively. The neem is known as Sarbaroganibarini